NMN (Nicotinamide Mononucleotide)
β-Nicotinamide Mononucleotide - Direct NAD+ Precursor
Replenishes NAD+, the cellular energy currency that declines 50% between ages 40 and 60. Restores mitochondrial function, DNA repair, and metabolic efficiency.
NAD+ powers every cell in your body - from energy production to DNA repair to circadian rhythm regulation. It declines sharply with age due to reduced synthesis and increased consumption by repair enzymes. NMN is the direct, most efficient precursor to NAD+ - converted rapidly in tissues.
Why NMN Over NR?
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NMN is one biosynthetic step closer to NAD+ than nicotinamide riboside (NR). Research shows NMN is transported directly into cells via the Slc12a8 transporter - bypassing the conversion step NR requires in plasma, meaning faster and more efficient NAD+ restoration.
■Published: Yoshino et al. (2021), Science - oral NMN supplementation increased NAD+ levels and improved muscle insulin sensitivity in older women over 10 weeks.
Ubiquinol - Active, Reduced Form
Powers ATP production in every cell. Essential for mitochondrial efficiency, heart function, and fatigue resistance. Declines with age and statin use.
CoQ10 is embedded in the inner mitochondrial membrane and is a critical component of the electron transport chain - the process that generates 95% of your body's ATP. It also functions as a powerful antioxidant within mitochondria, protecting them from oxidative damage during energy production.
Why 10mg in EVRA's Formula?
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CoQ10 is highly lipophilic and accumulates in tissues with daily use. EVRA's 10mg is a precision maintenance dose designed to work synergistically with NMN and PQQ - targeting energy production from three different angles simultaneously rather than in isolation.
■Published: Mortensen et al. (2014), JACC Heart Failure - CoQ10 supplementation significantly reduced mortality and improved symptoms in heart failure patients over 2 years.
PQQ (Pyrroloquinoline Quinone)
Pyrroloquinoline Quinone - Mitochondrial Biogenesis
Stimulates the creation of new mitochondria. The only nutrient known to trigger mitochondrial biogenesis - you don't just restore energy, you expand capacity.
PQQ activates PGC-1α, the master regulator of mitochondrial biogenesis. This means PQQ doesn't just help existing mitochondria work better (like CoQ10) - it signals the body to create entirely new mitochondria. More mitochondria means greater baseline energy capacity, better stress resilience, and improved cognitive function.
Why PQQ + NMN + CoQ10?
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These three work on different points: NMN restores the fuel (NAD+), CoQ10 improves engine efficiency (electron transport), and PQQ builds more engines (mitochondrial biogenesis). Together they deliver comprehensive mitochondrial restoration that no single ingredient achieves.
■Published: Nakano et al. (2012), Journal of Nutritional Biochemistry - PQQ supplementation significantly improved cognitive function and energy metabolism in middle-aged adults.
Methylcobalamin - Active Neurological Form
Powers red blood cell formation, neurological function, and DNA synthesis. Deficiency - common after 40 - causes fatigue, brain fog, and mood disruption.
B12 absorption declines with age due to reduced intrinsic factor production. Up to 20% of adults over 50 are deficient without knowing it. Symptoms - fatigue, poor concentration, low mood - are often attributed to stress or ageing, when the root cause is a simple, correctable deficiency.
Why Methylcobalamin?
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Methylcobalamin is the neurologically active form found in the brain and nervous system. Cyanocobalamin (the cheap form) must be converted before use and is less effective at crossing the blood-brain barrier. Methyl-B12 is used immediately, without conversion.
■Published: Skarupski et al. (2010), American Journal of Clinical Nutrition - higher B12 intake was significantly associated with slower cognitive decline in older adults.
Pyridoxine HCl - Metabolic Co-Factor
Essential co-factor in over 100 enzymatic reactions. Supports neurotransmitter synthesis (serotonin, dopamine, GABA), red blood cell metabolism, and homocysteine regulation.
B6 is the co-factor for enzymes that convert tryptophan to serotonin and tyrosine to dopamine - making it essential to mood regulation and energy metabolism. It also works with B12 to reduce homocysteine, a marker of cardiovascular risk that increases with age.
Why B6 With B12?
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B6 and B12 work together in the methionine cycle that regulates homocysteine. High homocysteine is an independent risk factor for cardiovascular disease and cognitive decline. Together they also support mood-regulating neurotransmitter pathways, delivering benefit across EVRA's Energy and Mood systems simultaneously.